Anna Mae Diehl, MD, Chief

Department:
Medicine

Division:
Gastroenterology

Physical Address:
DUMC 3913, Durham, NC 27710

Appointment Telephone:
(919) 684-6437

Fax Telephone:
(919) 684-8857

Training:
M.D., Georgetown University, Washington, D.C., 1978
Internal Medicine, Johns Hopkins University, Maryland, 1978-1981
Gastroenterology, Johns Hopkins University, Maryland, 1981-1984

Clinical Interests:
Liver disease, especially chronic metabolic liver diseases

Publications:
2008 -- Pubmed # 18471524 -- Jung Y, Brown KD, Witek RP, Omenetti A, Yang L, Vandongen M, Milton RJ, Hines IN, Rippe RA, Spahr L, Rubbia-Brandt L, Diehl AM. Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans. Gastroenterology. 2008 May;134(5):1532-43.

2008 -- Pubmed # 18218671 -- Omenetti A, Diehl AM. The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer. Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G595-8.

2008 -- Pubmed # 18375471 -- Omenetti A, Popov Y, Jung Y, Choi SS, Witek RP, Yang L, Brown KD, Schuppan D, Diehl AM. The Hedgehog Pathway Regulates Remodeling Responses to Biliary Obstruction in Rats. Gut. 2008 Mar 28.

2008 -- Pubmed # 18395287 -- Ouyang X, Cirillo P, Sautin Y, McCall S, Bruchette JL, Diehl AM, Johnson RJ, Abdelmalek MF. Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol. 2008 Jun;48(6):993-9.

2008 -- Pubmed # 18331237 -- Solga SF, Horska A, Hemker S, Crawford S, Diggs C, Diehl AM, Brancati FL, Clark JM. Hepatic fat and adenosine triphosphate measurement in overweight and obese adults using 1H and 31P magnetic resonance spectroscopy. Liver Int. 2008 May;28(5):675-81.

2008 -- Pubmed # 18000880 -- Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, Bhanot S, Monia BP, Li YX, Diehl AM. Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis. Hepatology. 2008 Feb;47(2):625-35.

2008 -- Pubmed # 18511600 -- Yang L, Jung Y, Omenetti A, Witek RP, Choi S, Vandongen HM, Huang J, Alpini GD, Diehl AM. Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells. 2008 Aug;26(8):2104-13.

2008 -- Pubmed # 18022723 -- Yang L, Wang Y, Mao H, Fleig S, Omenetti A, Brown KD, Sicklick JK, Li YX, Diehl AM. Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol. 2008 Jan;48(1):98-106.

2007 -- Pubmed # 17538998 -- Abdelmalek MF, Diehl AM. De Novo nonalcoholic fatty liver disease after liver transplantation. Liver Transpl. 2007 Jun;13(6):788-90.

2007 -- Pubmed # 17952094 -- Fleig SV, Choi SS, Yang L, Jung Y, Omenetti A, VanDongen HM, Huang J, Sicklick JK, Diehl AM. Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. Lab Invest. 2007 Dec;87(12):1227-39.

2007 -- Pubmed # 17464985 -- Jung Y, McCall SJ, Li YX, Diehl AM. Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis. Hepatology. 2007 May;45(5):1091-6.

2007 -- Pubmed # 17237799 -- Li YX, Yang HT, Zdanowicz M, Sicklick JK, Qi Y, Camp TJ, Diehl AM. Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling. Lab Invest. 2007 Mar;87(3):231-40.

2007 -- Pubmed # 17476695 -- Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, Bhanot S, Monia BP, Li YX, Diehl AM. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology. 2007 Jun;45(6):1366-74.

2007 -- Pubmed # 17476695 -- Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, Bhanot S, Monia BP, Li YX, Diehl AM. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology. 2007 Jun;45(6):1366-74.

2006 -- Pubmed # 16492691 -- Setji TL, Holland ND, Sanders LL, Pereira KC, Diehl AM, Brown AJ. Nonalcoholic steatohepatitis and nonalcoholic Fatty liver disease in young women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2006 May;91(5):1741-7.

2006 -- Pubmed # 16710052 -- Sicklick JK, Choi SS, Bustamante M, McCall SJ, Pérez EH, Huang J, Li YX, Rojkind M, Diehl AM. Evidence for epithelial-mesenchymal transitions in adult liver cells. Am J Physiol Gastrointest Liver Physiol. 2006 Oct;291(4):G575-83.

2006 -- Pubmed # 17010940 -- Zhao C, Chen W, Yang L, Chen L, Stimpson SA, Diehl AM. PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells. Biochem Biophys Res Commun. 2006 Nov 17;350(2):385-91.