John Mchutchison, MD, Director GI/Hepatology Research DCRI

Department:
Medicine

Division:
Gastroenterology

Physical Address:
DUMC 3850, Durham, NC 27710

Appointment Telephone:
(919) 668-7193

Fax Telephone:
(919) 668-7164

Training:
M.D., Melbourne University, Victoria, Australia, 1981
Internal Medicine, Royal Melbourne Hospital, Victoria, Australia, 1982-1985
Gastroenterology, Royal Melbourne Hospital, Victoria, Australia, 1986-1987
Hepatology, University Southern California, Los Angeles, California, 1988-1990

Clinical Interests:
Hepatitis B and C, ascites, noninvasive fibrosis markers, and steatosis

Publications:
2007 -- Pubmed # 17397412 -- McHutchison JG, Manns MP, Brown RS Jr, Reddy KR, Shiffman ML, Wong JB. Strategies for managing anemia in hepatitis C patients undergoing antiviral therapy.  Am J Gastroenterol.  2007 Apr;102(4):880-9.

2007 -- Pubmed # 17484890 -- Pawlotsky JM, Chevaliez S, McHutchison JG. The hepatitis C virus life cycle as a target for new antiviral therapies. Gastroenterology. 2007 May;132(5):1979-98.

2007 -- Pubmed # 17532523 -- Pockros PJ, Guyader D, Patton H, Tong MJ, Wright T, McHutchison JG, Meng TC. Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies. J Hepatol. 2007 Aug;47(2):174-82.

2007 -- Pubmed # 17625010 -- White IR, Patel K, Symonds WT, Dev A, Griffin P, Tsokanas N, Skehel M, Liu C, Zekry A, Cutler P, Gattu M, Rockey DC, Berrey MM, McHutchison JG. Serum proteomic analysis focused on fibrosis in patients with hepatitis C virus infection. J Transl Med. 2007 Jul 11;5(1):33.

2006 -- Pubmed # 16487617 -- Bain VG, Kaita KD, Yoshida EM, Swain MG, Heathcote EJ, Neumann AU, Fiscella M, Yu R, Osborn BL, Cronin PW, Freimuth WW, McHutchison JG, Subramanian GM. A phase 2 study to evaluate the antiviral activity, safety, and pharmacokinetics of recombinant human albumin-interferon alfa fusion protein in genotype 1 chronic hepatitis C patients. J Hepatol. 2006 Apr;44(4):671-8.

2006 -- Pubmed # 16731032 -- Bain VG, Yoshida EM, Kaita KD, Swain MG, Heathcote EJ, Garcia A, Moore PA, Yu R, McHutchison JG, Subramanian GM. Dynamics of interferon-specific gene expression in peripheral blood of interferon alfa-naïve patients with genotype 1 chronic hepatitis C infection treated with albumin-interferon alfa. Hepatol Res. 2006 Aug;35(4):256-62.

2006 -- Pubmed # 16682255 -- Dev A, Patel K, Conrad A, Blatt LM, McHutchison JG. Relationship of smoking and fibrosis in patients with chronic hepatitis C. Clin Gastroenterol Hepatol. 2006 Jun;4(6):797-801.

2006 -- Pubmed # 16401485 -- Dienstag JL, McHutchison JG. American Gastroenterological Association medical position statement on the management of hepatitis C. Gastroenterology. 2006 Jan;130(1):225-30.

2006 -- Pubmed # 16364491 -- McHutchison JG, Bartenschlager R, Patel K, Pawlotsky JM. The face of future hepatitis C antiviral drug development: recent biological and virologic advances and their translation to drug development and clinical practice. J Hepatol. 2006 Feb;44(2):411-21.

2006 -- Pubmed # 16274834 -- McHutchison JG, Patel K, Pockros P, Nyberg L, Pianko S, Yu RZ, Dorr FA, Kwoh TJ. A phase I trial of an antisense inhibitor of hepatitis C virus (ISIS 14803), administered to chronic hepatitis C patients. J Hepatol. 2006 Jan;44(1):88-96.

2006 -- Pubmed # 16644828 -- Patel K, Muir AJ, McHutchison JG. Diagnosis and treatment of chronic hepatitis C infection. BMJ. 2006 Apr 29;332(7548):1013-7.

2006 -- Pubmed # 16440356 -- Patel K, Norris S, Lebeck L, Feng A, Clare M, Pianko S, Portmann B, Blatt LM, Koziol J, Conrad A, McHutchison JG. HLA class I allelic diversity and progression of fibrosis in patients with chronic hepatitis C. Hepatology. 2006 Feb;43(2):241-9.

2005 -- Pubmed # 16232013 -- Bacon BR, McHutchison JG. Treatment issues with chronic hepatitis C: special populations and pharmacy strategies. Am J Manag Care. 2005 Oct;11(10 Suppl):S296-306; quiz S307-11.

2005 -- Pubmed # 16003247 -- Condron SL, Heneghan MA, Patel K, Dev A, McHutchison JG, Muir AJ. Effect of donor age on survival of liver transplant recipients with hepatitis C virus infection. Transplantation. 2005 Jul 15;80(1):145-8.

2005 -- Pubmed # 16317670 -- Grant WC, Jhaveri RR, McHutchison JG, Schulman KA, Kauf TL. Trends in health care resource use for hepatitis C virus infection in the United States. Hepatology. 2005 Dec;42(6):1406-13.

2005 -- Pubmed # 16232012 -- McHutchison JG, Bacon BR. Chronic hepatitis C: an age wave of disease burden. Am J Manag Care. 2005 Oct;11(10 Suppl):S286-95; quiz S307-11.

2005 -- Pubmed # 16152757 -- McHutchison JG, Shiffman ML, Cheung RC, Gordon SC, Wright TL, Pottage JC Jr, McNair L, Ette E, Moseley S, Alam J. A randomized, double-blind, placebo-controlled dose-escalation trial of merimepodib (VX-497) and interferon-alpha in previously untreated patients with chronic hepatitis C. Antivir Ther. 2005;10(5):635-43.